Extracellular matrix dynamics in tubulogenesis
نویسندگان
چکیده
منابع مشابه
Tubulogenesis: A Role for the Apical Extracellular Matrix?
The tube is a common shape in biology. Its function is to transport materials from one site to another. A contiguous lumen and a sealed wall to prevent leakage are critical features of tube design. For a tubular network to be effective, it also has to be deployed in the correct place. An example where this is particularly crucial is the tracheal system that mediates gas exchange in insects and ...
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The extracellular matrix (ECM) is an inherently dynamic structure during development. Large-scale tissue movements sweep the ECM to distant positions during early embryogenesis; furthermore, the previously assembled ECM filaments are extensively reused during later organogenesis. Thus, some organs, such as the heart, inherit previously assembled ECM filaments. This review focuses on the macro-a...
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OBJECTIVE This investigation aimed at determining the importance of the rigidity of the adhesive support and the participation of the cytoskeleton in tubulogenesis of endothelial cells in vitro. METHODS The morphotype, biosynthetic phenotype and cytoskeleton organization of human umbilical vein endothelial cells (HUVEC) were analyzed on supports of variable mechanical resistance. RESULTS We...
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The extracellular matrix (ECM) regulates cell behavior by influencing cell proliferation, survival, shape, migration and differentiation. Far from being a static structure, the ECM is constantly undergoing remodeling--i.e. assembly and degradation--particularly during the normal processes of development, differentiation and wound repair. When misregulated, this can contribute to disease. ECM as...
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Aligned fibers of extracellular matrix (ECM) affect the direction, efficiency, and persistence of migrating cells. To uncover the mechanisms by which multicellular tissues align their surrounding ECM before migration, we used an engineered three-dimensional culture model to investigate the dynamics of ECM alignment around tissues of defined geometry. Analysis of ECM alignment over time revealed...
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ژورنال
عنوان ژورنال: Cellular Signalling
سال: 2020
ISSN: 0898-6568
DOI: 10.1016/j.cellsig.2020.109619